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The radiochemistry laboratory contains two large volume "windowed" hot cells, four mini hot cells with remote TV monitoring, two radiochemistry hoods, laminar flow hood, two dedicated Nuclear Interface FDG synthesis modules, a general purpose Nuclear Interface C-11 synthesis module, a general purpose Nuclear Interface F-18 fluorination module, and a three chamber computer controlled AtomLab dose calibrator. Two computers are used for master formulary tracking. Real time tracking of potential radioactivity emissions and automated liquid target (O-18 water) operations are accomplished with PC systems. Operation of all cyclotron and target functions are routinely and remotely performed from the radiochemistry labs as well as other locations within the PET Center. |
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F-18 and O-15 are routinely prepared for human use. F-18 Fluorothymadine and C-11 are available for animal studies and are in Phase I human studies. An IND for F-18 FLT is being prepared and should be submitted by Sept. 2007. The cold chemistry labs (nonradioactive chemistry area) contain two chemistry hoods, one laminar flow hood, and a complete water purification system. |
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The Quality Assurance Laboratory contains a PC computer that controls a Bioscan radio-TLC scanner and two Dionex BioLC HPLC systems complete with electrochemical, variable wavelength UV and radioactivity detectors. Two radio-GC systems are available for gaseous compounds. All chromatographic systems are interfaced using National Instruments Lab View software with in-house customizations. Other instruments include dose calibrators and NaI (Tl) well counters for accurate determination of radioactivity (dose) and gamma spectroscopy of labeled radiopharmaceuticals. |
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