Radiopharmaceutical Production     Radioactive materials are transported from the cyclotron to the chemistry lab where chemists and technologists use automated synthesis systems from Nuclear Interface shown in the figure below to produce the P.E.T. radiotracer. The automated systems are located within lead-walled (5 cm thick) cabinets called "hot cells". Computers are used to program the synthesis systems. The precise composition of the radiotracer is assured by testing the products with one or more of the following techniques: gas chromatography (GC), high pressure liquid chromatography (HPLC), or thin layer chromatography (TLC) before administration to the patient. Sterility and pyrogen testing are performed on every dose.     Some of the radiotracers routinely produced at the University of Iowa are given in the following table: Radiotracer Injected Dose P.E.T. Imaging Use [15O]water 50 mCi Brain Blood Flow [11C]acetate 20 mCi Myocardial Flow and Metabolism [18F]FDG 10 mCi Brain, Heart, and Tumor Metabolism [18F]F- 5 mCi Bone Function [13N]amonia 25 mCi Myocardial Perfusion Related Pages Data Analysis Pet Imaging Radionuclide Production

Topics Overview | Patient Info | Facilities | Personnel | Research | Publications | Downloads Search | Home   This site is optimized for IE 4, Netscape 4 or later with a window size of 800 by 600 pixels. ©The University of Iowa 2004. All rights reserved.