Laura L. Boles Ponto, PhD

Associate Research Scientist

University of lowa	B.S. Ph.	1977	Pharmacy
University of lowa	M.S.	1981	Clinical Pharmacy
University of lowa	Ph.D.	1988	Pharmaceutics

Professional Experience

1977 - 1978	Director of Pharmacy Services, Long Beach Hospital, Long Beach, California
1978	Staff Pharmacist, Duke University Medical Center, Durham, North Carolina
1979 - 1987	Graduate Assistant, College of Pharmacy, University of lowa, lowa City, lowa
1988 - 1990	Research Assistant II, Dept. of Radiology, Div. of Nuclear Medicine, University of Iowa, Hospitals and Clinics, lowa City, lowa
1990 - 1995	Assistant Research Scientist, Department of Radiology, Division of Nuclear Medicine, P.E.T. Imaging Center, University of lowa, lowa City, lowa
1995 - present	Associate Research Scientist, Department of Radiology, Division of Nuclear Medicine, P.E.T. Imaging Center, University of lowa, lowa City, lowa
1995 - 1998	Consultant, Medical Imaging Drugs Advisory Committee, Food and Drug Administration, Rockville, Maryland
1998	Consultant, Medical Imaging Drugs Advisory Committee, FDA, Rockville, Maryland
1996 - present	Member, Editorial Board, Pharmacy Continuing Education Program, University of New Mexico

Awards

AZO Award	1975
Rho Chi	1976
Iowa Pharmaceutical Association, Women's Auxiliary Scholarship	1976
University of lowa, Hancher Commendation Award	1977
University of lowa, College of Pharmacy Faculty Award	1977
University of lowa, Finkbine Medallion Nominee	1977, 1980
University of lowa, College of Pharmacy Dean's List	1972 - 1977
American Foundation for Pharmaceutical Education Fellowship	1985 - 1987
Merck Pharmaceutics Fellow	1986, 1987

Address:

 

P.E.T. Imaging Center

Department of Radiology

University of Iowa Hospitals and Clinics

0911-Z JPP

200 Hawkins Drive

Iowa City, IA 52242-1009

 

Phone: 319-356-4102

FAX: 319-353-6512

E-mail: laura-ponto@uiowa.edu

Selected Publications

Ponto LLB, Perry PJ, Liskow BI, Seaba H. Drug Therapy Reviews: Tricyclic antidepressants and monoamine oxidase inhibitor combination therapy. Am J Hosp Pharm. 1977; 34: 954 - 961. and In: Drug Therapy Reviews, Volume Two. ed. Miller RR, Greenblatt DJ. New York: Elsevier/ North Holland; 1979.

Ponto LLB, Schoenwald RD. Furosemide: A pharmacokinetic/dynamic review I & II. Clin Pharmacokinetics. 1990; 18 (5): 381 - 408 and 18 (6): 460 - 471.

Ponto LLB, Schoenwald RD. Multiple linear regression modeling of furosemide renal clearance and urinary excretion rate. J Pharm Sci. 1991; 80: 1084 - 1091.

Ponto LLB, Ponto JA. Uses and limitations of positron emission tomography in clinical pharmacokinetics/dynamics. Clin Pharmacokinetics. 1992; 22(3): 211 - 222 & 22(4): 274 - 283.

Hurtig RR, Hichwa RD, O'Leary DS, Ponto LLB, Narayana S, Watkins GL, Andreasen NC. A quantitative assessment of the timing and duration of cognitive activation in [15O]water PET studies. J Cerebral Blood Flow Metab. 1994; 14: 423 - 430.

Hichwa RD, Ponto, LLB, Watkins GL. Clinical blood flow measurements with [15O]water and positron emission tomography (PET). In: Symposium proceedings of The International Symposium on "Chemists' Views of Imaging Centers". ed. Emran AM. New York: Plenum Publishing Corporation; 1995.

Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Watkins GL, Ponto LLB and Hichwa RD: Remembering the Past: Two facets of episodic memory explored with positron emission tomography. American Journal of Psychiatry, 1995; 152: 1576 - 1585.

Narayana S, Hichwa RD, Ponto LLB, Ponto JA, Watkins GL. Dosimetry of [15O]water: A physiologic approach. Med Phys. 1996; 23(1): 159 - 168.

O'Leary DS, Andreasen NC, Hurtig RR, Hichwa RD, Watkins GL, Ponto LLB, Rogers M, Kirchner PT. A positron emission tomography study of binaurally and dichotically presented stimuli: Effects of level of language and directed attention. Brain and Language. 1996; 53: 20 - 39.

Grabowski TJ, Frank RJ, Brown CK, Damasio H, Ponto LLB, Watkins GL, Hichwa RD. Reliability of PET activation across statistical methods, subject groups, and sample sizes. Human Brain Mapping. 1996; 4: 23 - 46.

Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K,Ponto LLB, Watkins GL, Hichwa RD. Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuity. Proc Natl Acad Sci. 1996; 93: 9985 - 9990.

Andreasen NC, Arndt S, Cizadlo T, O'Leary DS, Watkins GL, Ponto LLB, Hichwa RD. Sample size and statistical power in [15O]H2O studies of human cognition. J Cerebral Blood Flow Metab. 1996; 16: 804 - 816.

Paradiso S, Robinson RG, Andreasen NC, Downhill JE, Davidson RJ, Kirchner PT, Watkins GL, Ponto LLB, Hichwa RD. Emotional activation of limbic circuitry in elderly normal subjects in a PET study. Am J Psychiatry. 1997; 154 (3): 384 - 389.

Ponto LLB, Hichwa RD, Watkins GL, Richmond JC, Clark J, Koeppel JA, Hitt JM, Thompson RA. Influence of age and gender on central nervous system tissue concentrations of freely diffusible substances. Pharm Res. 1997; 14 (11-supplement): S511.

Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Ponto LLB, Hichwa RD. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients. Lancet. 1997; 349: 1730 - 1734.

Wollenweber SD, Hichwa RD, Ponto LLB. A simple on-line arterial time-activity curve detector for [O-15]water PET studies. IEEE Trans Nuclear Science. 1997; 44(4): 1613 - 1617.

Paradiso S, Facorro BC, Andreasen NC, O'Leary DS, Watkins LG, Ponto LLB, Hichwa RD. Brain activity assessed with PET during recall of word lists and narratives. NeuroReport. 1997; 8: 3091 - 3096.

O'Leary DS, Andreasen NC, Hurtig RR, Torres IJ, Flashman LA, Kesler ML, Arndt SV, Cizadlo TJ, Ponto LLB, Watkins GL, Hichwa RD. Auditory and visual attention assessed with PET. Human Brain Mapping. 1997; 5(6): 422 - 436.

Miller DD, Andreasen NC, O'Leary DS, Rezai K, Watkins GL, Ponto LLB, Hichwa RD. Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography. Neuropsychopharmacology. 1997; 17(4): 230 - 240.

Narayana S, Hichwa RD, Ponto LLB, Hurtig RR, Watkins GL. Construction of a whole body blood flow model for use in positron emission tomography imaging with [15O]water. J Pharmacokinet Biopharm. 1997; 25(5): 539 - 568.

Wiser AK, Andreasen NC, O'Leary DS, Watkins GL, Ponto LLB, Hichwa RD. Dysfunctional cortico-cerebellar circuits cause 'cognitive dysmetria' in schizophrenia. NeuroReport. 1998; 9(8): 1895 - 1899.

Ponto LLB, Madsen MT, Hichwa RD, Mayr N, Yuh WTC, Magnotta VA, Watkins GL, Ehrhardt JC. Assessment of blood flow in solid tumors using PET. Clin Positron Imaging. 1998; 1(2): 117 - 121, 1998.

Johnson DL, Wiebe JS, Gold SM, Andreasen NC, Hichwa RD, Watkins GL, Ponto LLB. Cerebral blood flow and personality: A positron emission tomography study. Am J Psychiatry. 1999; 156(2): 252 - 257.

Crespo-Facorro B, Paradiso S, Andreasen NC, O'Leary DS, Watkins GL, Ponto LLB, Hichwa RD. Recalling word lists reveals "cognitive dysmetria" in schizophrenia: A positron emission tomography study. Amer J Psychiatry. 1999; 156(3): 386 - 392.

Kim JJ, Andreasen NC, O'Leary DS, Wiser AK, Ponto LLB, Watkins GL, Hichwa RD. Direct comparison of the neural substrates of recognition memory for words and faces. Brain. 1999; 122: 1069 - 1083.

Schultz SK, O'Leary DS, Ponto LLB, Watkins GL, Hichwa RD, Andreasen NC. Age-related changes in regional cerebral blood flow among young to mid-life adults. NeuroReport. 1999; 10: 2493 - 2496.

Andreasen NC, O'Leary DS, Paradiso S, Cizadlo T, Arndt S, Watkins GL, Ponto LLB, Hichwa RD. The cerebellum plays a role in conscious episodic memory retrieval. Human Brain Mapping. 1999; 8: 226 - 234.

Paradiso S, Johnson DL, Andreasen NC, O'Leary DS, Watkins GL, Ponto LLB, Hichwa RD. Cerebral blood flow changes associated with attribution of emotional valence to pleasant, unpleasant, and neutral visual stimuli in a PET study of normal subjects. Amer J Psychiatry. 1999; 156: 1618 - 1629.

Block RI, O'Leary DS, Hichwa RD, Augustinack JC, Ponto LLB, Ghoneim MM, Arndt S, Ehrhardt JC, Hurtig RR, Watkins GL, Hall JA, Nathan PE, Andreasen NC. Cerebellar hypoactivity in frequent marijuana users. NeuroReport. 2000; 11: 749 - 753.

Kramer JR, Loney J, Ponto LB, Roberts MA, Grossman S. Predictors of adult height and weight in boys treated with methylphenidate for childhood behavior problems. J Am Acad Child Adolesc Psychiatry. 2000; 39(4): 517 - 524.

Wiser AK, Andreasen NC, O'Leary DS, Crespo-Facorro B, Ponto LLB, Watkins GL, Hichwa RD. Novel vs. well-learned memory for faces: A positron emission tomography study. J Cognitive Neurosci. 2000; 12(2): 255 - 266.