Richard D. Hichwa, PhD

Associate Professor

University of Notre Dame, South Bend, IN	B.S.	1975	Physics
Vanderbilt University, Nashville, TN		1976	Nuclear Physics
University of Wisconsin, Madison, WI	M.S.	1977	Medical Physics
University of Wisconsin, Madison, WI	Ph.D.	1981	Medical Physics

Professional Experience

1981-85	Assistant Research Scientist/Cyclotron Physicist, Positron Emission Tomography Facility, U of Michigan
1983-88	Director, Cyclotron/PET Facilities, U of Michigan
1983-88	Assistant Professor, Bioengineering Faculty, U of Michigan
1985-88	Assistant Professor, Dept. of Intern. Med., Div. of Nuc. Med., U of Michigan
1988-pr	Associate Professor, Dept. of Radiology, Div. of Nuclear Medicine, U of Iowa
1988-pr	Director, PET Imaging Center, University of Iowa

Address:

 

P.E.T. Imaging Center

Department of Radiology

University of Iowa Hospitals and Clinics

0911-Z JPP

200 Hawkins Drive

Iowa City, IA 52242-1009

 

Phone: 319-356-4104

FAX: 319-353-6512

E-mail: richard-hichwa@uiowa.edu

Selected Publications

Nickles RJ, Gatley SJ, Madsen MT, Hichwa RD, Simpkin DJ, Martin JL: High yield synthesis of the sequence 13N2, 13H20, 11C2H2, H215O and 17F-for rCBF studies. J Labeled Compounds 1979;16:9091.

 

Gatley SJ, Hichwa RD, Shaughnessy WJ, Nickles RJ: 18-F labeled lower fluoroalkanes; reactorproduced gaseous physiological tracers. Int J Appl Rad Isot 1981;32:211.

 

Madsen MT, Hichwa RD, Mckles RJ: An investigation of 11 [C-methane, 13N-nitrous oxide and 11Cacetylene as regional cerebral blood flow agents. Phys Med Biol 1981;26:875-882.

 

Hichwa RD, Nickles RJ: Targetry for the production of medical isotopes. EKE Trans Nucl Sci 1981;NS- 28:1924-1927.

 

Holden JE, Gatley SJ, Hichwa RD, Ip WR, Shaughnessy WJ, Nickles RJ, Polcyn RE: Cerebral blood flow using PET measurements of fluoromethane kinetics. J Nucl Med 1981;22:1084-1088.

 

Hichwa RD, Tsang C: A positron detector suitable for automated radiopharmaceutical production. J Label Comp Radiopharm 1982;19:1346.

 

Hichwa RD: Positron production and PET scanning. EKE Trans Nucl Sci 1983;NS-30:1688-1692.

 

Frey KA, Agranoff BW, Young AB, Hichwa RD, Ehrenkaufer RLE: Human brain receptor distribution. Science 1986;232:1269-1270.

 

Hutchins GD, Hichwa RD, Koeppe RA: A continuous flow input function detector for H215O blood flow studies in PET. I.E.E.E Trans Nucl Sci 1986;NS-33:546-549.

 

Hichwa RD, Hugel EA, Moskwa JJ, Raylman RR: Gas targets for the production of 150, 11C and 18F for PET studies. Nucl Instr Metho 1987;B24-25:932-936.

 

Young AB, Penney JB, Starosta-Rubinstein S, Markel DS, Berent S, Giordani B, Ehrenkaufer RL, Jewett D, Hichwa RD: PET scan investigations of Huntington's disease: cerebral metabolic correlates of neurologic features and functional decline. Ann Neurol 1987;20:296-303.

 

Koeppe RA, Hutchins GD, Rothley JM, Hichwa RD: Examination of assumptions for local cerebral blood flow studies in positron emission tomography. J Nucl Med 1987;27:1695-1703.

 

Abou-Khalil BW, Siegel GJ, Sackellares JC, Gilman S, Hichwa RD, Marshall R: Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy. Ann Neurol 1987;22:480-486.

 

Kooppe RA, Rosenspire KC, Price J, Hichwa RD, Mangner TJ, Betz AL, Agranoff BW: Effect of dietary aspartame on human brain carbon-11 aminocyclohexanecarboxylate (ACHC) uptake. J Nucl Med 1988;29:784-785.

 

Frey KA, Koeppe RA, Mulholland GK, Jewett DJ, Hichwa RD, Agranoff BW, Kuhl DE: Muscarinic receptor imaging in human brain using (C- 11) scopolamine and positron emission tomography. J Nucl Med 1988;29:808-809.

 

Junck L, Gilman S, Rothley JM, Betley AT, Koeppe RA, Hichwa RD: A relationship between metabolism in frontal lobes and cerebellum in normal subjects studied with PET. J Cereb Blood Flow Metabolism 1988;8:774-782.

 

Hichwa RD, Moskwa n, Hugel E: Design of target systems for production of positron nuclides. NIM 1989;B40/41:1110-1113.

 

Cameron OG, Modell J, Hichwa RD, Agranoff BW, Koeppe RA: Changes in sensory-cognitive input: Effects on cerebral blood flow. J Cereb Blood Flow Metabl 1990; 10:38-42.

 

Hichwa RD: Automation in PET center operation with special application to radiation monitoring. NIM l991;B56/57:1205-1207.

 

Hichwa RD, Johnston DJ, Ponto LL, Watkins GL: Handheld automated injector for O- 15 water studies. J Nucl Med 1991;32:1063.

 

Karp JS, Daube-Witherspoon ME, Hoffman EJ, Lewellen TK, Links JM, Wong WH, Hichwa RD, Casey ME, Colsher JG, Hitchens RE, Muehllehner G: Performance standards in Positron Emission Tomography. J Nucl Med 1991;32:2342-2350.

 

Hurtig RR, Hichwa RD, O'Leary DS, Boles Ponto LL, Narayana S, Watkins GL Andreasen NC: The effects of the timing and duration of cognitive activation of a 1s water PET studies. J Cereb Blood Flow Metab 1994;14:423-430.

 

Hichwa RD: Are animal scanners really necessary for PET? J Nucl Med 1994;35: 1396- 1397.

 

Kahn D, Weiner GJ, Ben-Haim S, Boles Ponto LL, Madsen MT, Bushnell DL, Watkins GL, Argenyi EE, and Hichwa RD: Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults. Blood 1994;4:958-963.

 

Hichwa RD, Kadrmas D, Watkins GL, Wollenweber SD, Maniam S, Boles Ponto LL, Richmond JCW, Koeppel JA: V-48: A renewable source for transmission scanning with PET. Nucl Instr Metho in Physics Res l995;B99:804-806.

 

Andreasen NC, O'Leary DS, Arndt S, Cizadlo T, Hurtig R, Rezai K, Watkins GL, Ponto LLB, Hichwa RD: Short-term and long-term verbal memory: A PET study. Proc Nat Acad Science 1995;5111 - 5115.

 

Grabowski TJ, Damasio H, Frank RJ, Brown CK, Boles Ponto LL, Watkins GL, Hichwa RD: Neuroanatomical analysis of functional brain images: Validation with retinotopic mapping. Human Brain Mapping 1995;2:134-148.

 

Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Watkins GL, Ponto LLB, Hichwa RD: PET studies of memory: Novel vs practiced free recall of word lists. Neuroimage 1995;2:284-295..

 

Andreasen NC,O'Leary DS,Cizadlo T, Arndt S, Rezai K, Watkins GL, Ponto LLB and Hichwa RD: Remembering the past: Two facets of episodic memory explored with positron emission tomography. Am J Psychiatry 1995; 152:1576- 1585.

 

Uygur GS, Hanson PS, Kirchner PT, Argenyi EE, Ponto LB, Watkins GL and Hichwa RD: [F18]FDG PET evaluation of malignant thoracic lesions. Radiol 1995;197(p):420.

 

Argenyi EE, Boles Ponto LL, Hichwa RD, Watkins GL, Kirchner PT and Ryals TJ: Follow-up of treatment of a cerebral Arteriovenous malformation with acetazolamide and positron emission tomography. Clin Nucl Med 1995;20:639-641.

 

Narayana S, Hichwa RD, Boles Ponto LL, Ponto J and Watkins GL: Dosimetry of [O-l5]water: A physiologic approach. Med Phys 1996;23: 159-168.

 

Grabowski TJ, Frank RJ, Brown CK, Damasio H, Boles Ponto LL, Watkins GL and Hichwa RD: Reliability of PET activation across statistical methods, subject groups, and sample sizes. Human Brain Mapping 1996;4:23-46.

 

O'Leary DS, Andreasen NC, Hurtig RR, Hichwa RD, Watkins GL, Boles Ponto LL, Rogers M and Kirchner PT: A positron emission tomography study of binaurally and dichotically presented stimuli: Effects of level of language and directed attention. Brain and Language 1996;53:20-39.

 

Andreasen NC, O'Leary DS, Arndt S, Cizadlo T, Hurtig R, Rezai K, Watkins GL, Boles Ponto L and Hichwa RD: Neural substates of facial recognition. J Neuropsychiatry 1996;8:139-146.

 

Damasio H, Grabowski TJ, Tranel D, Hichwa RD and Damasio AR: A neural basis for lexical retrieval. Nature 1996;380:499-486.