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Publications by Tim Tewson, Ph.D

1. Anger, I.R., Tewson, T.J., Phillips, L., Wray, V.: 19F Nuclear magnetic resonance studies of aromatic compounds. Part II. The 19F chemical shifts in meta- and para-substituted flurobenzens, and 4-substituted 3'-4'-fluoro-trans-stillbenes. J.C.S. Perkins Trans. II:1979-1983, 1972.

2. Barton, D.H.R., Hesse, R.H., Pechet, M.M., Tewson, T.J.: Synthesis of 12-fluoro-corticosteroids. J.C.S. Perkins Trans. I: 2395-2401, 1973.

3. Taylor, R., Tewson, T.J.: Concerning the (-complex mechanism for aromatic substitution. Detritiation in trifluoromethane sulphonic acid. J.C.S. Chem. Comm. 836-837, 1973.

4. Tewson, T.J.: Bistrifluoromethylhydroxylamine-O-trifluoromethane sulphonate. Nucleophilic attach on nitrogen. J. Fluorine Chem. 101-108, 1976.

5. Tewson, T.J., Welch, M.J.: New approaches to the synthesis of 3-deoxy-3-fluoro-D-glucose. J. Org. Chem. 43:1090-1094, 1978.

6. Tewson, T.J., Welch, M.J., Raichile, M.E.: 18F-labeled 3-deoxy-3-fluoro-glucose: Synthesis and preliminary biodistribution data. J. Nucl. Med. 19:2339-2346.

7. Bergman, S.R., Hack, S.N., Tewson, T.J., Welch, M.J., Sobel, B.E.: The dependence of accumulation of 13NH3 by myocardium on metabolic factors and its implications for quantitative assessment of perfusion. Curc. 61:34-42, 1980.

8. Tewson, T.J., Welch, M.J.: "No carrier added" 18F-fluoroethanol, synthesis and preliminary biodistribution. J. Nucl. Med., 21:559-568, 1980.

9. Tewson, T.J., Welch, M.J., Raichle, M.E.: Preliminary studies with 18F-Haloperidol: a radioligand for in vivo studies of the dopamine receptor. Brain Res. 192:291-295, 1980.

10. Tewson, T.J., Welch, M.J., Raichle, M.E.: Preparation of fluorine-18 aryl fluoride: piperidyl triazenes as a source of diazonium salts. J.C.S. Chem. Com., 1149-1151, 1979.

11. Tewson, T.J., Maeda, M., Welch, M.J.: Preparation of no carrier added 18F-aryl fluorides: conditions and scope of reaction. J. Lab Cmpds. Radiopharm., 18:21, 1981.

12. Maeda, M., Tewson, T.J., Welch, M.J.: Preparation of no carrier added 18F-spiroperidol. J. Lab. Cmpds. Radiopharm., 18:192, 1981.

13. Berridge, M., Tewson, T.J., Welch, M.J.: Preparation of 18F-7-fluoropalmitic acid. J. Lab. Cmpds. Radiopharm., 18:102, 1981.

14. Tewson, T.J., Cyclic sulphur esters as substrates for nucleophillic substitution. J. Org. Chem. 48:3507-3570, 1983.

15. Tewson, T.J.: Synthesis of no carrier added fluorine-18 2-deoxy-2-fluoro-glucose. J. Nucl. Med. 24:718-821, 1983.

16. Kilbourn, M.R., Welch, M.J., Dence, C.S, Tewson, T.J., Saji, H., Maeda, M.: Carrier added and no carrier added synthesis of [18F] spiroperidol and [18F] haloperidol. Int. J. Appl. Radiat. and Isotopes 35:591-598, 1984.

17. Berridge, M., Rosenfeld, E., Tewson, T.J.: Cyclic sulfates as substrates for nucleophilic substitution. Fifth International Symposium on Radiopharmaceutical Chemistry, J. Lab. Cmpds. Radiopharm. 21: 1184-5 1984

18. Tewson, T.J., Soderlind, M.: 1-Propenyl-4,6-benzylidene ß-mannopyranoside-2,3-cyclic sulfate: A substrate for the synthesis of F-18-2-deoxy-2-fluoro-glucose. J. Carbohydrate Chem. 4:529-541, 1985.

19. Berridge, M.S., Tewson, T.J.: Effects of target design on the production and utilization of [F-18]-fluoride from [0-18]-water. J. Lab. Cmpds. Radiopharm. 23 117-9, 1986.

20. Tewson, T.J., Berridge, M.S., Soderlind, M., Vaidya, M.: Labelled ligands for the in vivo measurement of the beta adrenergic receptor. J. Lab. Cmpds. Radiopharm. 23 1412, 1986

21. Gould, K.L., Goldstein, R.A., Mullani, N.A., Kirkeeide, R.L., Wong, W.H., Tewson, T.J., Berridge, M.S., Bolomey, L.A., Hartz, R.K., Smalling, R.W., et al: Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced rubidium-82. J. Am. Coll. Cardiol. 7(4). P 775-89 1986.

22. Berridge, M.S., Franceschini, M.P., Tewson, T.J., Gould, K.L.: Preparation of oxygen-15 butanol for positron tomography. J. Nucl. Med. 27:834-8, 1986.

23. Berridge, M.S., Tewson, T.J.: Chemistry of fluorine-18. Int. J. Appl. Radiat. Isotopes 37:6850-693, 1986.

24. Tewson, T.J., Berridge, M.S., Bolomey, L., Gould, K.L.: Effects of target design on the production of [F-18] fluoride from oxygen-18 water. Int. J. Appl. Radiat. Isot. 15:49-504, 1988.

25. Bank, W., Tewson, T.J., Digenis, G.: Synthesis of Carbon-11 Alprazolam. A Diazepam Receptor Agonist. J. Lab. Cmpds. Radiopharm. 26: 69-71, 1989

26. Tewson, T.J., Banks, W., Franceschini, M.P., Hoffpauir, J.: A trap for the removal of oxides of nitrogen from Carbon-11 Carbon Dioxide. Appl. Radiat. Isot. 40:765-768, 1989.

27. Mossberg, K.A., Rowe, R.W., Tewson, T.J., and Taegtmeyer, H.: Rabbit hindlimb glucose uptake assessed with positron emitting fluorodeoxyglucose. J. Appl. Physiol. 67:1569-77, 1989

28. Tewson, T.J.: Procedures, Pitfalls and Solutions in the Production of [F-18]-2-Deoxy-2-Fluoro-D-glucose: A Paradigm in the Routine Synthesis of Fluorine-18 Radiopharmaceuticals, J. Nucl. Med. and Biol. 16:533-561, 1989.

29. Banks, W.R., Dignneis, G.A., Tewson, T.J., Smith, R., and Fleishaker, J.: 1-[11C]-Alprazolam: A receptor Agonist for In Vivo Studies of the Benzodiazepine Receptor. Appl. Radiat. Isot. 41:719-726, 1990.

30. Berridge, M.S., Rosenfeld, P., Franceschini, M.P., Tewson, T.J.: Cyclic sulfates as substrates for nucleophilic substitution: scope and limitations of the substitution reaction. J. Org. Chem. 55:1211-1216, 1990.

31. Overturf, M., Smith, S., Gotta, A., Marrsett, J., Tewson, T.J., Pooman, J., and Loose-Mitchell, D.: Dietary Cholesterol Absorption, and Sterol and Bile Acid Excretion in Hypercholesterolimia-Resistant White Rabbits. J. Lipid Research 31:2019-2027, 1990.

32. Nguyen, V.T.B., Mossberg, K.A., Tewson, T.J., Wong, W.H., Rowe, R.W., Coleman, G.M., and Taegtmeyer, H.: Assessment of myocardial glucose metabolism by 18-F-2-deoxy-2-fluoro-D- glucose: Effects of work load, competing substrates and insulin. Am. J. Physiology, Heart and Circulatory Physiology H1022-1032 1990.

33. Tewson, T.J., Kinsey, B.M., and Franceschini, M.P.: Synthesis of Fluorine-18 fluoroalkyl pindolol derivatives: Ligands for the (-adrenergic receptor. J. Lab. Cmpds. Radiopharm. 30: 385-386 1991

34. Kinsey, B.M. and Tewson, T.J.: Fluorine-18 fluoroalkyl derivatives of carazalol: potential ligands for the In Vivo studies of the (-adrenergic receptor. J. Lab. Cmpds. Radiopharm. 30: 373-4 1991

35. Dobbs, F.R., Banks, W.A., Fleishaker, J.C., Digenis, G.A., and Tewson, T.J.: The routine synthesis of carbon-11 alprazolam utilizing carbon-11 acetyl chloride as a synthetic intermediate. J. Lab. Cmpds. Radiopharm. 30: 230-233 1991

36. Tewson, T.J., Franceschini, M., Scheule, R., Holian, A.: Labelling of Asbestos Fibres. Appl. Radiat. Isot. 42 499-504 1991.

37. Michael Merhige, Dahlia Garza, David Sease, R. Wanda Rowe, Timothy Tewson, Ali Emran, Leonard Bolomey and K. Lance Gould. Quantitation of the Critically Ischemic Zone at Risk During Acute Conorary Artery Occlusion Using PET. J. Nucl. Med. 1991 32: 1581-1586

38. Yang, D.J., Tewson T.J., Tansey, W., Li-Ren, Yuang, Regger, G., Cherif, A., Wright, K.C., Moult, R.G., Tilbury R.S., , Wallace, S.: Halogenated Analogs of Tamoxifen: Synthesis, Receptor Assay and Inhibition of MCF7 Cells J. Pharm. Sci. 81 622-625 1992

39. Tewson T.J. Synthesis Fluorine-18 Lomefloxacin, A fluorinated quinoline antibiotic. J. Lab. Cmpds. Radiopharm. 32; 145-146 1993

40. Kinsey B.M., Barber R. Tewson T.J., Synthesis of Fluorine-18 Fluorocarazolol: A ligand for the (-adrenergic receptor. J. Lab. Cmpds. Radiopharm. 32: 298-299 1993.

41. Kinsey B.M. Tewson T.J. Synthesis of No Carrier Added Fluorine-18 Fluoroacetone, a useful Synthetic Intermediate. J. Lab. Cmpds. Radiopharm. 32:300-302 1993.

42. Dobbs F.R., Franceschini M.P., Tewson T.J The Routine Synthesis of Carbon-11 Phosgene, An Intermediate to Carbon-11 2-Thymine. J. Lab. Cmpds. Radiopharm. 32: 191-193 1993

43. Tewson T.J., Fleishaker J.C., Dobbs F,Banks W, Digenis G.A., PET Studies with 11C - Alprazolam; An Agonist for the Benzodiazepine Receptor J. Nucl. Med and Biol. 22 459-466 1995

44. Tewson, K. Sadilkova, C. Supuran and E Swenson The Synthesis Of Fluorine-18 Labeled Carbonic Anhydrase IV Inhibitors: Selectivity By Exclusion. J. Lab. Cmpds and Radiopharm. 37 237-239 1995.

45. Tewson T.J. The Routine Synthesis Of Fluorine-18 16(-Fluoroestradiol: The Use Of 3-Methoxymethyl-Epiestriol-16(,17(-Cyclic Sulfate As The Starting Substrate. J. Lab. Cmpds and Radiopharm. 37 589-591 1995

46. Tewson T.J., D.Yang, G.Wong, D. Macy, O.J.DeJesus, R.J. Nickles, S.B. Perlman, M. Taylor, P. Frank. The Synthesis of Fluorine-18 Lomefloxacin and its Preliminary Use in Human Studies J. Nucl. Med. and Biol. 23 767-772, 1996.

47. Lim J.L., Lei Zheng, M.S. Berridge, and T.J. Tewson. The use of 3-methoxymethyl-16(,17(-epiestriol-O-cyclic sulfone as the precursor in the synthesis of F-18 16(-fluoroestradiol. J. Nucl. Med. and Biol. 23 911-915, 1996.

48. Mankoff D.M., Tewson T. J. Eary J.F. Analysis of the Blood Clearance and Metabolism for the Estrogen Receptor Tracer, [F-18] 16(-Fluoroestradiol (FES). J. Nucl. Med. and Biol. 24 341-348 1997.

49. T. J. Tewson. Synthesis of F-18 Fluoroetanidazole: a Potential New Tracer for Imaging Hypoxia. J. Nucl. Med. and Biol. 24 755-760 1997

50. T. J. Tewson. Synthesis of [F-18]-Fluoroetanidazole - A New Nitroimidazole Tracer of Hypoxia. J. Lab. Cmpds. and Radiopharm. 40 56-57 1997

51. T. J. Tewson, Svetlana Stekhova. Synthesis of the Stereoisomers of [F-18]-Fluoropropanolol, a Tracer for the (-Adrenergic Receptor. J. Lab. Cmpds. and Radiopharm.40 58-59 1997.

52. T. J. Tewson, Eric G. Shankland, Margaret T. Tewson, Akana Wada, Linda Weins, and Kenneth A. Krohn. N,N-Dimethyl-3-mercapto-4,4,4-trifluorobutylamine; A Potential Agent for the NMR Measurement of the Cytosolic Redox State. J. Med. Chem. Submitted.

53. T. J. Tewson and K. A. Krohn, PET Radiopharmaceuticals: State of the Art and Future Prospects. Seminars in Nuclear Medicine. 28 221-234 1998

54. Janet S. Rasey, Phillip D. Hofstrand, Lay K. Chin and Timothy J. Tewson. Charaterization of [F-18]Fluoroetanidazole, a New Radiopharmaceutical for Detecting Tumor Hypoxia. J. Nucl. Med. 40 1072-1079 1999

55. Timothy J. Tewson, Svetlana Stekhova, Berma Kinsey, Lay Chin, Linda Wiens and Roger Barber. Synthesis and Biodistribution of the stereoisomers of [F-18]-Fluoropropanolol, a Tracer for the (-Adrenergic Receptor. Nucl. Med. and Biol. 26 891-896, 1999

56. Tewson T. J. Mankoff D. A. Peterson L.M, Woo I., and Petra P. The Interactions of 16(-[18F]-Fluoroestradiol (FES) with Sex Steroid Binding Protein (SBP). Nucl. Med. and Biol. 26 905-913 1999

57. Tewson T. J. Enzyme Inhibition as an Aid to Simplify Pharmacokinetic Measurments.

J. Nucl. Med. 41 1725-26 2000

58. David A. Mankoff, Lanell M. Peterson, Timothy J. Tewson, Jeanne M. Link, Julie R. Gralow, Michael M. Graham, Kenneth A. Krohn, [F-18]Fluoroestradiol Radiation Dosimetry in Human PET Imaging Studies. J. Nucl. Med. 42 679-684 2001

59. Swenson ER. Tewson TJ. Wistrand PJ. Ridderstrale Y. Tu C. Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretion. American Journal of Physiology - Gastrointestinal & Liver Physiology. 281:G61-8, 2001.

60. P. Doze, A. van Waarde, T.J. Tewson W. Vaalburg, P.H. Elsinga. Synthesis and evaluation of (S)-[18F]-fluoroethylcarazolol for in vivo beta-adrenoceptor imaging in the brain. Neurochemistry International 41 17-27 2002.

61. Jeffrey J. Posakony John R. Grierson Timothy J. Tewson.New Routes to N-Alkylated Cyclic Sulfamidates. J. Org. Chem., 67 (15), 5164 -5169, 2002

62. Jeffrey J. Posakony, Timothy J. Tewson. Substitution Reactions of Hindered Cyclic Sulfamidates. Synthesis 859-864 2002

63. Jeffrey J. Posakony. Timothy J. Tewson. Fluoroamines via Chiral and Hindered Cyclic Sulfamidates. Synthesis 766-770 2002

64. T. J. Tewson. Labeled Antibiotics: Positron Tomography as a Tool for Measuring Tissue Distribution. Drug Development Research 59: 261-268 2003