Authors

Ponto LL. Ponto JA.

Institution

PET Imaging Center, Department of Radiology, University of Iowa, Iowa City.

Title

Uses and limitations of positron emission tomography in clinical pharmacokinetics/dynamics (Part II). [Review] [180 refs]

Source

Clinical Pharmacokinetics. 22(4):274-83, 1992 Apr.

Abstract

Positron emission tomography (PET) involves imaging the biodistribution and tissue localisation of small amounts of radiolabelled biomolecules or drugs. In Part I of this article, which appeared in the previous issue of the Journal, the applications of pharmacokinetics in PET were discussed in order to derive quantitative measures of physiological function. Part II examines the use of PET imaging as a tool to study the pharmacokinetics and pharmacodynamics of specific drugs. [References: 180]